I admired her serenity in the midst of so much chaos. Sep 30, 2005 · Serenity: Directed by Joss Whedon. In this continuation of the television series "Firefly," a group of rebels travels the outskirts of space aboard their ship, Serenity, outside the reach of the Alliance, a sinister regime that The meaning of SERENITY is a state of utter calm and unruffled repose or quietude. The meaning of SERENITY is a state of utter calm and unruffled repose or quietude. Louis area and 1 office in Columbia, MO, specializing in outpatient psychiatric services including medication management. The meaning of SERENITY is a state of utter calm and unruffled repose or quietude. See examples of serenity used in a sentence. With Nathan Fillion, Gina Torres, Chiwetel Ejiofor, Alan Tudyk. SERENITY definition: the state or quality of being serene, calm, or tranquil; sereneness. The hotel offers a tranquil haven of peace and serenity, away from the bustle of the city.